• The immune control of CMV replication in vivo is

  2019-09-17

  

  The immune control of CMV replication in vivo is primarily driven by the T-cell-mediated response, a characteristic that has been proposed as a tool to individualize and therefore to optimize antiviral treatment [6], [7], and it has been associated with spontaneous clearance of CMV viraemia in patie

• Estrogen receptors ERs belong to the third class of

  2019-09-16

  

  Estrogen receptors (ERs) belong to the third class of nuclear receptors (NR3) [23]. Two different forms of ER have been described, ERα and ERβ. They are coded by two distinct genes (ESR1 and ESR2, respectively) containing 8 transcribed exons that give rise to six conserved protein domains: domains A

• Introduction Breast cancer is a highly

  2019-09-16

  

  Introduction Breast cancer is a highly prevalent malignancy. There are some recognized risk factors for breast cancer, like early menarche or late menopause, which increase the length of the exposure to hormones, as a result of a higher number of ovarian cycles [1]. Moreover, there is evidence supp

• br Diverse functions of ERK pathway Same as the other

  2019-09-16

  

  Diverse functions of ERK pathway Same as the other MAPK cascades, the ERK pathway is activated by several extracellular stimuli and different internal routes. ERK vitally tunes the function of various substrates in all cellular components; the nucleus, cytoplasm, membranes and the cytoskeleton. E

• br Results and discussion br Conclusions In this work

  2019-09-16

  

  Results and discussion Conclusions In this work, we have conjugated two thermophilic enzymes (i.e., AMY and LASPO) to iron oxide NPs through different conjugation strategies obtaining efficient biocatalysts. We have demonstrated that these NP-enzyme systems can be successfully activated by an

• br Halogenases Enzymatic C H activation leading to halogenat

  2019-09-16

  

  Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical

• br Results br Discussion The

  2019-09-16

  

  Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor trans-4-Hydroxycrotonic acid kinase within the GC. The identification here of a distinct subset

• The relatively less well studied encodes the E type SUMO

  2019-09-16

  

  The relatively less well-studied encodes the E2 type SUMO-conjugating enzyme. In plants, the SCE family members play roles in abiotic stress responses. An E2 enzyme, SaSce9, from plays roles in salinity and drought stress responses (). Furthermore, SCE can respond to heat stress in rice (). Howeve

• Several highly potent CysLT receptor antagonists with large

  2019-09-16

  

  Several highly potent CysLT1 receptor antagonists with large structural DCG IV have been developed. Beyond antagonists with structures analogous to cysteinyl leukotrienes, other subclasses comprise: (a) hydroxyacetophenones, (b) indoles and indazoles, (c) quinolines, benzothiazoles, and thiazoles.

• br Materials and methods br Results

  2019-09-16

  

  Materials and methods Results Discussion NB has been shown to induce cancers in many tissues including the kidney, liver, and thyroid, following chronic inhalation in animals (Hsu et al., 2007). The available data indicate that a lager majority of studies on NB evaluate the effects of toxic

• br Chondroitin sulfate proteoglycans CSPGs are major compone

  2019-09-12

  

  Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix in cartilage. Each CSPG comprises a single core protein and attached chondroitin sulfate (CS), belonging to the glycosaminoglycan family of sugar chains. CSPGs and CS are involved in numerous biological and

• In our xenograft study Fig Fig we observed that

  2019-09-12

  

  In our xenograft study (Fig. 7, Fig. 8), we observed that DYD acts very similarly to progesterone; the initial faster tumor growth in the PGRMC1-transfected MCF7 tumor was not significant compared with that with progesterone, in smo inhibitor to the greater tumor growth observed with norethisterone

• br Effects of estradiol outside the nucleus are often mediat

  2019-09-12

  

  Effects of estradiol outside the nucleus are often mediated by classical estrogen receptors Today, it is widely accepted that steroid hormones can signal in ways that do not rely on receptors acting in the nucleus, including activation of receptors localized to the cellular membrane. Rapid effect

• Across the scaffold the platform anchors the N

  2019-09-12

  

  Across the scaffold, the platform anchors the N terminus of the elongated cullin structure of APC2 [21]. This connects to the flexible cullin–RING catalytic core consisting of the C-terminal region of APC2 and the associated APC11 11, 12, 21. The flexibility and positions of the catalytic core are c

• Here we also took attempt to evaluate the

  2019-09-12

  

  Here we also took attempt to evaluate the CYP mediated inhibition potential of S. chirata and its biomarker ursolic deoxycorticosterone on pooled RLM by CYP-CO complex assay. We observed that S. chirata extract and ursolic acid showed less enzyme inhibition than known inhibitor (ketoconazole). It e

16006 records 986/1068 page Previous Next First page 上5页 986987988989990 下5页 Last page